Alteration of succinate dehydrogenase activity in rat liver mitochondria by 1,3,4-thiadiazine class compounds in vitro

In present article we report the effects of 1,3,4-thiadiazine class derivatives, such as L-2, L-4, L-6 synthesized in Ural federal University under the leadership of academician O.N. Chupahin on the mitochondrial succinate dehydrogenase of rat liver in vitro. It is shown that unlike L-6 substance which has no significant effect on enzyme activity, L-2 and L-4 compounds inhibit succinate dehydrogenase to varying degrees, reducing its activity in the 2 and 4-fold, respectively, compared with native mitochondria (p