The changes of biochemical indicators in rats' blood at feeding them with milk with the addition of formic acid

For gastrointestinal diseases prophylaxis in young growth the technology of milk souring with formic acid is widely used. However, the data on safety of formic acid as a preservative of forages are contradictory. The research objective was to determine changes in biochemical indicators of blood serum in laboratory rats at feeding them with milk with addition of formic acid within 30 days. The experiment was conducted on 2 groups of white laboratory rats with 12 specimens in each at the age of 6 months with the body weight of 240-260 g. One group of rats received milk with addition of formic acid (30 ml of 8.5 % formic acid for one liter of milk). Milk was daily fed on in the volume of 30-40 ml per a head within 30 days. Control animals received fresh milk. Biochemical parameters have been tested with the automatic biochemical analyz-er "SCREEN MASTER-PLUS" by Hospitex diag-nostics (Italy). Statistical data have been analyzed by means of the Statistica 6.0 program. Nonpara-metric criterion Mann - Whitney have been used in group comparing. Daily feeding with milk with addi-tion of formic acid causes in rats increased ALAT and ASAT levels, alkaline phosphatase and amyl-ase, and also creatinin and urea in blood serum that indicated a high risk of lesions in kidneys as well as in liver and digestive tract in productive an-imals when using the specified technology in pro-duction. Clinical state of animals within a month remained satisfactory complicating prognostic as-sessment of formic acid-related adverse effect when used as a preservative.