Changes in Physiological Blood Constants in Comorbid Patients after COVID-19

Clinical and laboratory parameters of hospital outpatient cards of patients with concomitant chronic diseases (comorbid patients) in 4 age groups from 30‒41, 41‒50, 51‒60, 61 and above years discharged from the city infectious diseases hospital in Osh were assessed and analyzed. In the examined comorbid patients, the physiological constants of the blood changed depending on the age and concomitant diseases of the patient before infection with SOVID-19. The aim of the study was to investigate the impact of various combinations of comorbidities in patients before SARS-CoV-2 infection on the severity and outcomes of the new coronavirus infection. The object of the study was the biochemical blood parameters of 86 hospital outpatient cards of patients with concomitant chronic diseases (comorbid patients) aged 30‒61 years discharged from the city infectious diseases hospital in Oshduring the SARS-CoV-2 viral infection of 2021 from the districts of Osh region, Batken region and Osh city of the Kyrgyz Republic. The results showed that the severity of the infection in patients depended on their chronic diseases: hypertension (HTN), diabetes mellitus (DM), obesity (OJ), chronic exacerbation of pulmonary disease (CEPD), rheumatoid arthritis (RA), coronary heart disease (CHD), cardiovascular failure (CVF), iron deficiency anemia (IDA). The effect of various combinations of comorbidities in patients before SARS-CoV-2 infection on the severity and outcomes of the new coronavirus infection was studied. The paper analyzes the impact of various combinations of concomitant diseases in patients before SARS-CoV-2 infection on the severity and outcomes of the new coronavirus infection. Clinical and laboratory indicators demonstrate the dynamics of decreased saturation in comorbid patients in the age category of 50 and above. It was shown that in the incubation period, from day 1 to day 14, and in the early phase of the disease (COVID-19), the number of leukocytes and lymphocytes in the peripheral blood was normal or slightly reduced. Platelet measurements showed that many patients had indicators within the normal range (from 57‒67%), only in age groups 1 and 4, thrombocytopenia was observed from 20‒22%, in groups 1, 3, 4, thrombocytosis from 29‒33%.