Changes in the activity of cerebral MAO-A and contents of monoamins - neurotransmitters in a long period of post-stress and steroid-induced involution of the adrenals

One of the most common types of post-traumatic stress disorder (PTSD) is complex post-traumatic stress disorder, which most often follows chronic stress or repeated adverse events such as slavery, genocide, longterm domestic violence, or repeated child sexual or physical abuse. At the same time, complex PTSD is accompanied by various complications of internal organs, among which adrenal dysfunction is most common. In turn, the uniqueness of our proposed experimental model of PTSD is that it was characterized by a decrease in the level of corticosterone both in the blood and in the adrenal glands themselves, meanwhile, in most experimental models of PTSD, the level of corticosterone increased sharply. The aim of this study was to study the relationship between the level of activity of monoamine oxidase-A (MAO-A) and the content of norepinephrine, dopamine and serotonin 14 days after the administration of a high dose of triamcinolone acetonide (TA). Post-traumatic stress disorders were modeled in Wistar rats by the smell of a predator (cat urine). Steroid-induced involution of the adrenal glands was modeled by administering to animals a single prolonged glucocorticoid preparation triamcinolone acetonide. The level of corticosterone was determined in the adrenal glands and blood plasma. The content of biogenic amines and the activity of basal MAO-A were determined in the brain. Comparison of iatrogenic and post-stress adrenal insufficiency confirms that it is glucocorticoids that play a key role in stress-realizing mechanisms and that with a decrease in glucocorticoids, the neurochemical profile associated with the growth of anxiety-depressive disorders changes.