The study of antigenicity, immunogenicity and protective potential of DNA constructs containing fragments of genes CP204L, E183l or EP402R of African swine fever virus strain MK-200

African swine fever (ASF) is a viral, contagious and septic disease affecting wild and domestic pigs of all breeds and age groups. In both domestic pigs and wild European boars affected, some hyperacute or acute forms of the infection are observed which are characterized by fever, signs of toxicosis, hemorrhagic diathesis with mortality rates of up to 100 %. In endemic regions (e.g., some countries of East Africa), a subacute form of the disease with a mortality of 30 to 70 %, as well as a chronic one with very low mortality levels are reported (S. Blome et al., 2013; C. Gabriel et al., 2011; JM Sánchez -Vizcaíno et al., 2015). No vaccine against African swine fever is currently available, and the research works aimed at the development of live, inactivated and subunit vaccines have not achieved the intended result yet (P.J. Sánchez-Cordón et al., 2017; V. O’Donnell et al., 2016; S. Blome et al., 2014). Nevertheless, the opportunity of obtaining a DNA vaccine using the genes of potentially protective ASFV proteins p30, p54 and/or CD2v is considered to be a promising option in a number of laboratories worldwide...