Study of association of polymorphic variants of serum and glucocorticoid-inducible kinase 1 gene with alcoholism

Serum and glucocorticoid-inducible kinase 1 (SGK1) gene is a key early response to stress gene. SGK1 is involved in many intracellular signaling pathways, in the regulation of the neuroexcitability hormones release, inflammation and cell proliferation, inhibits apoptosis, playing important role in the pathophysiology of brain diseases. In this paper we tested the hypothesis that polymorphic variants rs9373085, rs1743964, rs1743966, rs1057293 of gene SGK1 are associated with alcoholism. The study included 182 male alcoholic patients. The control group consisted of 101 healthy men. Comparing the frequencies of genotypes and alleles in groups of alcoholics and controls showed no significant differences.