Study of the frequency of meeting of genotypesof the Leu28Pro polymorphic marker of the APOE gene in diabetic nephropathy in patients with type 2 diabetes

The aim of this study was to study 129 patients with type 2 diabetes and 110 healthy people to determine whether the Leu28Pro polymorphic markers of the APOE gene are associated with the development of diabetic nephropathy (DN). Patients in the main group: 65 patients with a disease duration of up to 10 years, without diabetic nephropathy (33 patients) and with diabetic nephropathy (32 patients), 64 patients with diabetes lasting more than 10-20 years, with no diabetic nephropathy (31 patients ) and diabetic nephropathy (33 patients). Genotyping was carried out by polymerase chain reaction. The study showed that the association of the Pro allele and the Leu / Pro genotype of the ENOS3 gene play a role in the development of diabetic nephropathy in patients with type 2 diabetes mellitus in the studied Uzbek nation.