Study of the action probiotics "Bioocok +" on rabbits with long-term application

The authors carried out research on the toxicological effect of the developed probiotic «BioSok+» on rabbits with prolonged use. The developed probiotic preparation includes a consortium of bacteria of the genus Propionibacterium, Lactobacillus and Lactococcus. The total content of propionic and lactic acid bacteria in 1 ml of probiotic is not less than 1 x 1010 CFU (colony-forming unit). The experiments were carried out on rabbits of the «Soviet Chinchilla» breed, divided into 2 groups of 4 animals each. The first group served as biological control and received a basic diet. The second group of animals additionally received the preparation «BioSok+» for 30 days. In the course of the experiments, the clinical state of animals, feed and water intake, survival, hematologic indices and pathoanatomical picture were studied. Based on the conducted studies, it was established that the probiotic preparation «BioSok+» with long-term administration does not exert a toxic effect on the rabbits organism. At the same time, against the background of giving the drug in experimental animals, in comparison with the control, there was a slight increase in body weight and blood element level, which may be evidence of an increase in total metabolism.