Study of markers of apoptosis, proliferation, and angiogenesis in patients ovarian cancer treated with accompanying immunotherapy

The aim of the work was to study a number of molecular biological tumor markers as selection criteria methods of accompanying extracorporeal immunopharmacotherapy (EIFT) in patients with ovarian cancer (OC). The object of the study were 30 patients with OC with II-III clinical stages of the disease who were treated in gynecological cancer RORC MoH Uzbekistan office from 2009 to 2011 years and treated with standard combination therapy. Most of the patients with OC (83.3, 86.7 and 80.0%, respectively) were present molecular biological markers p53, VEGF and Ki-67. At the same time, the markers HER-2/neu and EGFR were found in 20.0% of patients and 30.0 respectively. It is shown that the greatest prognostic value regarding the efficacy of the treatment of patients with OC have tumor markers p53, VEGF and Ki-67, and the level of proliferative activity (PA) of the tumor. The greatest effect in increasing the 5-year survival of patients immunotherapy has provided the accompanying diagram including EIFT with plasmapheresis. Positive okomarkerov level of p53, VEGF and Ki-67 in patients with OC, along with high PA tumors can serve as a basis for this category of patients with immunotherapy accompanying EIFT. In the case of positive values of all the above molecular biological factors, we recommend carrying out the accompanying EIFT with plasmapheresis, which can significantly increase the effectiveness of standard anticancer treatment schemes.