Study of the (+)-erogorgiane antimicrobial action mechanisms

The antibacterial activity of a chemically synthesized counterpart of natural antibiotic (+) - erogorgiane extracted from marine coral Pseudopterogorgia elisabethae was studied. This substance has been shown to have bactericidal effect against Mycobacterium smegmatis culture in both logarithmic and stationary growth phases. At the same time, gram negative Escherichia coli is resistant to this compound. The concentration-dependent inhibition of M. smegmatis biofilm formation under sublethal antibiotic action has been observed. The effect of the test compound on the cell surface structure was detected with atomic force microscopy. The attempts to obtain antibiotic resistant mutants on agar media with high antibiotic concentrations failed.