Study of the oxidative processes in rat heart tissue in nitric oxide deficit modeling
Автор: Medvedev D.V., Zvyagina V.I.
Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk
Рубрика: Лабораторные и экспериментальные исследования
Статья в выпуске: 2 т.28, 2013 года.
Бесплатный доступ
The purpose of this study was to investigate the effects of decrease in the nitric oxide metabolite content, induced by a nonselective inhibitor of NOsynthase, LNGnitroarginine methyl ester (LNAME), on the activity of succinate dehydrogenase and superoxide dismutase and on the rate of spontaneous protein oxidation in the rat heart. Data showed that the treatment with LNAME dosedependently decreased the level of nitric oxide metabolites in blood serum and, to a lesser degree, in the rat heart. Inhibition of nitric oxide synthesis by LNAME caused a dosedependent decrease in spontaneous protein oxidation in the rat heart due to, perhaps, the changes in the activity of mitochondrial enzymes.
L-ng-нитроаргинина метиловый эфир (l-name), nitric oxide, l-ng-nitroarginine methyl ester (l-name), oxidative modification of proteins, superoxide dismutase, succinate dehydrogenase, mitochondria
Короткий адрес: https://sciup.org/14919855
IDR: 14919855
