Study of the acute oral toxicity of a new feed additive of egg poultry

The aim of the study is to assess the acute toxicity of a new feed additive for egg poultry under the code "T-1.4". The experiments were carried out on laboratory animals – nonlinear white rats, formed into groups according to the principle of analogues. The studied feed additive was administered to animals intragastrically in the dose range from 1800 mg/kg to 2600 mg/kg of body weight. It was found that LD50 detected by the method of Pershin G.N. was a value equal to (2270 ± 66.60) mg/kg. Using the Miller and Tainter probit analysis, LD16 and LD84 were determined, amounting to 2090 mg/kg and 2455 mg/kg of body weight, respectively. Based on the results of research (external examination, weighing) in animals receiving a feed additive in doses close to LD0- LD16, a positive dynamics of body weight gain was established, while the general condition of the animals, their coat and the condition of the mucous membranes practically did not differ from the condition of the animals of the control group. In groups of laboratory animals to which "T-1.4" was administered at doses close to LD50 - LD100, the body weight gain was lower relative to the control values by an average of 20-25%. At the same time, there was a decrease in mobility, slight sedation. Based on the results of the conducted studies, it can be concluded that the feed additive "T-1.4" belongs to the 3rd hazard class (moderately dangerous substances).