Study of polymorphism of DNA repair genes in the formation of presposition to the development of triple negative breast cancer in women

The study involved 682 women of Russian nationality living in Kemerovo oblast of Russia, including 213 patients with triple-negative breast cancer and 249 women of a similar age with no signs of cancer. Comparative analysis of polymorphic variants of DNA repair genes APEX1 444T>G (rs1130409), ATM5557G >A (Ars180151), hOGG1 977C>G (rs1052133), XPD 2251T>G (rs13181), XPG 3310G>C (rs17655), ADPRT 2285 T>C (rs11610) in patients with triple-negative breast cancer and individuals without cancer living in the same area was performed. Analysis of single-locus effects showed significant associations between the risk of breast cancer and variants of the XPG 3310G>C gene (rs17655) (OR = 0.64, CI: 0.47-0.87, p = 0.004) in the overall group and (OR = 0.68, 95% CI: 0.49 -0.94; p = 0.019) in the non-smoking group, and the XPD 2251T>G gene (OR = 0.30, 95% CI: 0.11-0.78; p = 0.011) in the smoking group. MDR analysis of intergenic interactions showed that the XPD 2251T>G and APEX1 444T>G, XPG 3310G>C and ATM 5557G>A genes closely interact and mutually increase the risk of developing breast cancer in women.