Efficiency of pharmacotherapy of bipolar affective disorder comorbid with personality disorder

Objective: the comparative study of the efficiency of conducted pharmacotherapy of the current depressive episode in the case of comorbidity of bipolar affective disorder (BAD) with personality disorder (PD) and in the case of bipolar affective disorder without such comorbidity. Material: The main group - 20 patients suffering from bipolar affective disorder with personality disorder. The group of comparison included 20 patients with the diagnosis of bipolar affective disorder, but without presence of comorbid PD. Methods: clinical-psychopathological, psychometric (SIGH-SAD, CGI-S, CGI-I, Udvald for Kliniske Undersogelser Scale), statistical. Results: results of the study showed that presence of comorbid PD in the case of BAD caused major severity of the current depressive episode (predominantly due to atypical depressive symptoms) than in the case of “pure” BAD. The need of applying combined psychopharmacotherapy appeared more frequently, therapeutic response was characterized by a slower reduction of depressive symptoms (also predominantly due to atypical depressive symptoms). Major severity of side effects from conducted psychopharmacotherapy and their slower reduction by weeks 2 and 4 of the therapy were documented. Conclusion. The findings confirmed the need of further studies for developing the most optimal therapeutic approaches in the case of comorbidity of bipolar affective disorder with personality disorder.