The efficiency of immunochromotographic method of identifying heart-type fatty acid-binding protein used for early differential diagnostics of acute coronary syndrome

The efficiency of immunochromotographic method of identifying heart-type fatty acid-binding protein (h-FABR) used for early differential diagnostics of acute coronary syndrome is assessed. The group consisted of 108 patients (average age - 65,20±1,22 years old) who were hospitalized urgently with supposed acute myocardial infarction (AMI) within the first 24 hours of the disease. All the patients have undergone immunochromotographic express-test, defining the level of h-FABR 15 ng/ml which is diagnostic for AMI. ROC-analysis proved high reliability of immunochromotographic method of identifying h-FABR in case of AMI in the test group (AUC 0.898) and also in the subgroup of patients without rise in ST segment (AUC 0.860). This method of diagnostics proved to be highly efficient within 1-3 hours (AUC 0.873) and 3-6 hours (AUC 0.877) since the start of the disease cliniclal presentations when definition of heart troponins is not considered informative even if high-sensitivity diagnosticum is applied.