Efficiency of non-opioid analgesics in patients with traumatic limb amputations in the early postoperative period

Justification: This work is the integration of safer and more effective drugs into clinical practice to optimize pain relief and reduce the risks associated with the use of traditional opioid analgesics. Objective: to evaluate the effectiveness of pain relief in the early postoperative period using non-opioid analgesics (ibuprofen, tafalgin, nefopam) in patients with mine-blast wounds (MBW) accompanied by traumatic amputations of the limbs. Methods: The study included 45 patients randomly assigned to three groups depending on the analgesic used: ibuprofen, tafalgin or nefopam. Results: In all groups, there was a significant decrease in the need for additional postoperative analgesia, including opioid drugs. Nefopam provided the most pronounced analgesic effect, reducing pain intensity on the VAS scale more than ibuprofen and tafalgin. However, its use was accompanied by a higher frequency of side effects (dizziness, tachycardia, hypertension). Ibuprofen demonstrated an optimal combination of analgesic efficacy and safety, with a minimal frequency of side effects. Conclusion: Nefopam has a pronounced analgesic effect in the early postoperative period in patients with MVR, but is associated with an increased frequency of side effects. Ibuprofen showed a high level of safety and sufficient efficacy, which makes it a preferred component of multimodal analgesia for this category of patients.