Efficacy of supramolecular complex of ivermectin in strongylatoses of sheep

The purpose of the study is to show the prospects of using the mechanochemical modification of the physicochemical and biological properties of the ivermectin substance (IVM) using the polyvinylpyrrolidone (PVP) polymer. The solid dispersion of the composition INM:PVP (1:9) /TDIP/ obtained by mechanical processing had a high solubility and was used to study the parasitocidal activity in strongylatoses of sheep. Experiments to assess the activity of drugs in intestinal and pulmonary helminthiases of sheep were carried out on a flock of spontaneously infested animals in the Altai Region. According to the principle of analogues, 6 experimental and 1 control groups of animals were formed. TDIP samples were given to sheep individually in the form of an aqueous suspension orally, at an IVM dosage of 0,1; 0,2; 0,3; 0,4 mg per kg of animal weight (m. f.), initial substances of the INM at 0,1 and 0,2 mg per kg of w. f. Efficacy was evaluated 15 days after the administration of the drugs by examining the experimental and control groups of animals using Fulleborn ovoscopy and Berman-Orlov larvoscopy, counting eggs of intestinal strongylates and larvae of pulmonary strongylates using the VIGIS method. Parasitocidal activity of TDIP in terms of intensity in a dose of 0,1 and 0,2 mg per kg of m.zh. with intestinal strongylatoses was 99.9 and 100%, respectively, with pulmonary strongylatoses - 83,0 and 100 %. The original substance of INM in these dosages was less effective. The possibility of a significant reduction in the dosage of IVM in compositions based on TDIP without reducing the parasiticidal activity of the drug was shown.