The efficiency soluble form of hypericin by radiation influence on Drosophila melanogaster

The biological activity and radiomodifying properties of the water-soluble form of hypericin for example Drosophila melanogaster were estimated. It is shown that the introduction in diet of test preparation of chronically irradiated (3,5 mGy/h) flies cause ambiguous of responses depending on the concentration of the substance, the temporal characteristics of the influence of each of the factors and genotypic characteristics of animals (at the level of fecundity, survival and the frequency of DNA damage). In the context of the joint effect of irradiation of hypericin and yield of DNA strand breaks in cells of both wild type Oregon-R (drug concentration at 10 and 100 µM) and lines Sod Delta02 / + (at concentrations not exceeding 100 µM) significantly below the level of the induced split their action. In terms of viability was observed only a few significant changes in response to the interaction of the agents studied. These data suggest that hypericin has an antioxidant effect in cells of irradiated individuals with impairments in the production of Mn-containing superoxide dismutase.