Experimental substantiation of the results of combined techniques in treatment of soft tissue abscess

Objective: to develop a model of purulent abscess of soft tissues and experimentally substantiate the efectiveness of the use of nanoparticles of zinc oxide (ZОN) and a drug based on lanthanum nitrate in the combined treatment of purulent abscess of soft tissues. Material and Methods. The purulent abscess of soft tissues modeling was performed using a modifed Fogarty catheter using a culture of Staphylococcus aureus in an experiment on 80 white laboratory rats of males weighing 190±25 g. Four groups of animals (20 each) were selected, which, after surgical dissection and laser rehabilitation of the cavity, carried out local therapy. In the frst (control) group, standard treatment was used, in the second group a drug based on lanthanum nitrate was used, in the third - ZОN, in the fourth - a combination of the drug with lanthanum nitrate + ZОN. Results. By the 10th day, 87±4.9 % of animals of the fourth group showed activation of the processes of collagenosis and epithelialization and complete obliteration of the abscess cavity. Conclusion. The developed purulent abscess of soft tissues modeling method is low-impact and allows optimizing the time of abscess formation with specifed characteristics. The combined treatment of animals of the fourth group due to the synergism of action creates optimal conditions for the accelerated obliteration of the purulent abscess of soft tissues cavity, shortening the treatment time by two times compared with the standard techniques.