Experimental models of transgenerational effects of the influence of estrogens on the morphology of reproductive organs in postnatal ontogenesis

In the modern clinical practice there is an increase in the use of hormones, their analogues and substances with hormone-like action in medical practice for the regulation of the menstrual cycle, conception, prevention, maintenance and resolution of pregnancy. According to official reports, in recent years, the number of annual cycles of assisted reproductive technology with hormonal support has increased six times in the country. The purpose of the review is to summarize current data on the effects of experimental and clinical effects of various doses of estrogens and drugs with estrogenic effects during the period of prenatal development on the morphology of the reproductive organs of the offspring in postnatal ontogenesis. The materials for the meta-analysis of the data were the results of relevant studies of domestic and foreign authors and their own published data. The article summarizes current data demonstrating the effects of experimental effects of various doses of estrogen and drugs with an estrogenic effect during the period of prenatal development on the morphology of the reproductive organs of the offspring in postnatal ontogenesis. The data on therapeutic, subtoxic and toxic doses of the effects of estrogen preparations in various experimental models are summarized, causing latent and morphologically manifested changes in the reproductive organs of the offspring.