Expression of CD68+, BCL-2+, KI-67+ in sentinel, native and postnatal induced lymph nodes

Immunohistochemically features of postnatal induced lymph nodes in comparison with sentinel and native lymph nodes in the experiment were studied. For the postnatal formation of lymph nodes, an experiment was performed on 25 white male rats of the Wistar line. The first group of animals (15 rats) was treated with sarcoma M1, the second group consisted of intact animals (10 rats). In the experiment, the possibility of reproducing postnatal induction of neolymphogenesis in tumor growth was demonstrated in the model of sarcoma M1. The study demonstrated a high level of antigen stimulation of T and B lymphocytes in postnatal induced lymph nodes and showed the possible role of macrophage cells in stimulating neolymphogenesis and the formation of new lymph nodes.