Expression of molecular-biological markers in breast tumors

Findings of retrospective immunohistochemical study of Ki-67, PCNA, Bcl-2, BAX, BclX, VEGF expressions in tumors of breast cancer patients with favorable and unfavorable prognosis have been presented. A significantly high level of VEGF expression was detected in tumors of patients with early breast cancer recurrence. Parallel with VEGF, the elevated levels of Ki-67 and PCNA expressions were also observed in tumors of these patients. The values of VEGF, Ki-67 and PCNA expressions in primary tumors are expected can be used for determining the breast cancer prognosis and screening the groups at high risk for early disease recurrence.