NEDD9 scaffolding protein expression as a negative prediction marker in non-small cell lung cancer (NSCLC)

The purpose of the study was to assess the prognostic significance of a scaffolding Nedd9 protein in patients with non-small cell lung cancer (Nsclc). Nedd9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as pi3K-aKt-mtoR, Ras-eRK, which play key roles in tumor progression. several studies define the regulatory role of Nedd9 in progression of several solid cancers, including non-small cell lung cancer (Nsclc), however its role as a prediction biomarker is minimally assessed. materials and methods. in the current study quantitative immunohistochemical (iHc) approach was utilized to characterize Nedd9 expression in a cohort of Nsclc primary tumor samples (n=16), and correlative statistical analysis was performed between Nedd9 expression and a set of patients’ clinical and pathological characteristics. Results of the iHc analysis were validated using broader tcga RNaseq dataset (n=566). Results. the study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages ii and iV (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }