Expression of cancer testis antigens in human melanoma cells
Автор: Mikhaylova I.N., Kovalevsky D.A., Burova O.S., Golubeva V.A., Morozova L.F., Voronina E.S., Utyashev I.A., Allakhverdyan G.S., Subramanian S., Kondrateva T.T., Cheremushkin E.A., Kiselev S.L., Demidov L.V., Baryshnikov A.Yu., Beabealashvilli R.Sh.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Лабораторные и экспериментальные исследования
Статья в выпуске: 1 (37), 2010 года.
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The expression of genes for 15 cancer-testis antigens and 4 melanoma differentiation antigens in 21 metastatic melanoma cell lines using a RT-PCR assay was analysed. The morphological examination allowed us to divide all analyzed cell lines into three groups with a high, intermediate, and low level of differentiation of tumour cells. Correlation analysis of gene expression and cell morphology demonstrated interrelation between increased expression of cancer-testis genes and differentiation grade of cancer cells. Data obtained can be used for the disease prognosis and promote optimization of medical treatment.
Cancer testis antigens, cellular differentiation, melanoma
Короткий адрес: https://sciup.org/14055590
IDR: 14055590
