Extracorporal detoxication in intensive therapy of severe sepsis

Sepsis and septic shock are the main causes of system dysfunction in many organs and death in the intensive care unit. The pathogenesis of sepsis is complex and consists of a network of interconnected pathways. For these reasons, an immunomodulatory strategy should restore immunological stability, and not inhibit or stimulate one or another component of this complex network. Therefore, the focus of immunomodulatory therapy in sepsis should be directed to non-specifi methods of influencing the entire inflammatory response without suppressing it. Over the past few decades huge changes have occurred in the approach to the choice of methods of molecular transfusiology in critically ill patients.Th s study provides an analytical review of current literature on the issue of extracorporeal detoxifi ation in intensive care for severe sepsis. It has been shown that extracorporeal detoxifi ation in sepsis, from the perspective of evidence-based medicine, is an effective direction in the treatment of severe sepsis.