Extracorporeal indirect electrochemical blood oxidation in urological diseases

This article is devoted to the description of the method of extracorporeal indirect electrochemical blood oxidation (EIEBO) in urological patients with infectious inflammatory complications and grade I endotoxicosis. The distinguishing feature of the EIEBO from the adopted intracorporeal method of oxidation is that blood is being processed using 0.06% solution of the sodium hypochlorite (SH) within the venous extracorporeal line, created using special equipment. The dose of the 0.06% SH solution, which is used for one seance of the EIEBO, is 0.75 mg/kg. Two liters of patient’s blood are being processed. The catheterization of the central vein is not necessary during EIEBO and the latter could be performed in the ambulatory setting. The peculiarities of the EIEBO with the 0.06% SH solution in patients with infectious inflammatory diseases of the urogenital tract and grade I endotoxicosis are: 1) prominent immunostimulation with regard to the absolute quantity of practically all subpopulations of the lymphocytes; 2) significant increase in the IgG concentration 7-10 days after the application of the method; 3) activation of the oxygen consumption and glycolysis; 4) increase in the hemostatic potential of the coagulation system; 5) safety in terms of the influence on the main homeostasis parameters.