Electro-physiological myocardial abnormalities at uncontrolled arterial hypertension in patients with genetic polymorphism of renin-angiotensin system and nitric oxide synthase

The paper gives a comparative evaluation of electro-physiological heart abnormalities in patients with controlled (n=50) and uncontrolled (n=75) arterial hypertension depending on genetic polymorphism renin-angiotensin system and nitric oxide synthase. Occurrence of DD genetic polymorphism in ACE gene, CC polymorphism in AT2R1 gene and also 4b/4b polymorphism in eNOS gene is associated with nonhomogeneity of electrical processes in atria and ventricles, delayed and fragmented myocardial activity in the form of late ventricular potential, which are more apparent in patients with uncontrolled arterial hypertension.