Electrocardiographic manifеstation of the myocardial dispersion of repolarization: interval Tpeak-Tend under experimental coronary occlusion and reperfusion

The heterogeneity of ventricular repolarization is essential for the T wave development on the ECG and for the genesis of fatal ventricular arrhythmias. Current study showed that the global, apicobasal, borderline dispersion increased significantly while transmural dispersion of repolarization duration and end of repolarization time in the ischemic zone did not demonstrate any differences under experimental coronary occlusion and reperfusion; dispersion of end of repolarization time is the better predictor of arrhythmogenesis than dispersion of repolarization duration; the global dispersion of repolarization had the greatest influence on the Tpeak-Tend interval changes compared to local transmural and borderline dispersions of repolarization.