Clinical and biological predictors of efficacy of electroconvulsive therapy in suicidal behavior in patients with mental disorders

The review article discusses the use of electroconvulsive therapy (ECT) for mentally ill patients with suicidal behavior. It describes the main electrophysiological mechanisms and therapeutic effects (antidepressant, antimanic, antipsychotic, etc.) of ECT, its safety and efficacy, clinical predictors in various mental disorders (affective/ depressive disorders, substance abuse disorders, schizophrenia, post-traumatic stress disorder, eating disorders, etc.). The rapid, but often relatively short-term effect of ECT on suicidal behavior is confirmed. Therefore, supporting ECT that is usually carried out in semi-inpatient (outpatient) conditions can help many patients with conditions resistant to psychopharmacotherapy and persistent suicidal behavior. ECT is still a rarely used method of treating and preventing suicidal behavior, especially in Russia. Integration of clinical and biological markers. The integration of the efficacy of ECT in suicidal behavior into a specific treatment algorithm may facilitate the development of a personalized therapeutic approach to the use of ECT. This will allow the identification of subgroups of individuals who are likely to respond to ECT. And the use of maintenance ECT, taking into account predictors of efficacy in treatment-resistant patients with high-risk mental disorders, opens up new prospects for the prevention of suicidal behavior.