Endogenous intoxication in the dynamics of acute obstructive cholestasis in rats

135 males of white rats of 200-250 gr have unvergone the ligature procedure of the bile duct or the procedure of the false operation (control group). The evaluation of the endogenous intoxication according to the content of the tyrosine-containing peptides (TCP) in the blood plasma and the brain has been carried out in 2-5 days after the procedure. In the dynamics of the obstructive chlestasis the content of TCP in the blood plasma stays elevated on the course of the entire experiment. The content of TCP in the brain in all the days after the procidure, except for the second day, is low.