Endothelial dysfunction in new coronavirus infection COVID-19

The article presents the processes of pathogenesis and clinic of a new coronavirus infection. According to the results of studies that have studied the pathogenesis of SARS-CoV and MERS-CoV, thrombotic complications are most common for infections caused by coronaviruses, and SARS-CoV-2 infection is no exception. The defeat of many organs is caused by several factors: the virus is tropic to tissues rich in the enzyme ACE2, expressed in such important structures as the gastrointestinal tract, kidneys, mucous membranes of the respiratory tract, cardiovascular and nervous system. Secondly, activation of the complement system and disruption of the urokinase pathway explain thromboses. The effect of estrogen on the protection of the endothelium from oxidative stress explains the higher mortality in men. Thus, the study of pathogenesis can influence the therapeutic approach to the treatment of this disease and contributes to the prevention of severe complications.