Эндотелиальная дисфункция при новой коронавирусной инфекции COVID-19

Эндотелиальная дисфункция при новой коронавирусной инфекции COVID-19

Автор: Михеенко П.В.

Журнал: Мировая наука @science-j

Рубрика: Основной раздел

Статья в выпуске: 1 (58), 2022 года.

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В обзоре освящены процессы патогенеза и клиники новой коронавирусной инфекции. Согласно результатам исследований, изучавших патогенез SARS-CoV и MERS-CoV, тромботические осложнения являются наиболее характерными для инфекций, вызванных коронавирусами, и инфекция SARS-CoV-2 не является исключением. Полиорганное поражение вызвано наличием нескольких факторов: вирус тропен к тканям, богатым ферментом АПФ2, экспрессирующемся в таких важных структурах, как желудочно-кишечный тракт, почки, слизистые оболочки дыхательных путей, сердечно-сосудистая и нервная система. Во-вторых, активация системы комплемента и нарушение урокиназного пути объясняют тромбозы. Влияние эстрогена на защиту эндотелия от окислительного стресса объясняет более высокую смертность у мужчин. Таким образом, подробное изучение патогенеза может повлиять на терапевтический подход к лечению данного заболевания и способствует предупреждению тяжелых осложнений.

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Коронавирусная инфекция, эндотелиальная дисфункция, тромбоз, патогенез, оксид азота

Короткий адрес: https://sciup.org/140289285

IDR: 140289285

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