Eradication therapy in children: the choice of the optimal treatment regimen

The review is devoted to the choice of the optimal treatment regimen of eradication therapy in children. Main tasks in the treatment of children with gastroduodenal pathology associated with Helicobacter pylori are eradication of the pathogen, restoration of the damaged mucosa and prevention of recurrence of the infection. A particular importance in the composition of eradication schemes is the choice of antibacterial drugs. The main requirements for anti-Helicobacter therapy regimens used in pediatric practice are: eradication rate of at least 80 %, economic accessibility, good tolerability with minimal severity of adverse reactions, optimal frequency of admission. An analysis of a number of domestic and foreign studies has shown that insufcient adherence of the patient to therapy, the presence of antibacterial resistance, pathogenicity factors in a number of strains of H. pylori have a negative efect on the efectiveness of treatment and should also be taken into account when choosing therapeutic tactics. Successful eradication of H. pylori in most cases depends on the optimal treatment regimen also has an impact on the result.