Estrogens and modulation of hypothalamo-pituitary-thyroid axis in chronic endogenous intoxication in rats

The structural and functional disorders in hypothalamo-pituitary-thyroid axis were revealed in chron ic endogenous intoxication. The modulation of estrogens was shown both when they were excessive (moderate protective action), and in estrogen deficiency (more severe duration of endogenous intoxication). In the latter case more significant structural changes in thyroid grand were found.