Identification of ethnogenetic differences in genetic markers in the clinical course and damage to target organs in arterial hypertension in Russians and Buryats

Aim. To study the influence of genetic factors on the severity of essential arterial hypertension (AH) clinical outcomes in patients of Russian and Buryat ethnicity. Methods. Our study included 206 patients with a diagnosis of essential AH: 136 patients were of Russian and 70 patients were of Buryat ethnicity. Patients were evaluated for the following genotype markers; ACE, ADRB1, ADRB2, ADRB3, NOS3, AGT, EDN1, GNB3, and STK39. Results. Allele T of GNB3 was associated with high blood pressure in Russian and Buryat patients. In Buryat patients, locus rs934379 of EDN1 was associated with high blood pressure, whereas allele G of the same marker was associated with increased heart damage risk. In Russians, allele I of ACE was protective towards the development of left ventricular hypertrophy. Conclusion. Our data revealed ethnogenetic differences in the genetic features of essential AH. We identified the patients severe hypertension among two etnhic group. Studying ethnic genetic markers for essential AH facilitates a greater understanding of the genetic predisposition underlying this condition.