Ethoxyresorufin o-deethylase -systematic accessory and its functional features of phase I enzyme of xenobiotics biotransformation (review)

Ethoxyresorufin o-deethylase (EROD) is nonspecific mono-oksigenaza (1.14.14.1) which belongs to the 1 class of enzymes (oxidoreductase). EROD is a representative of the big gemprotein family designated as P450 oytochrome present practically in all animal and plant cells (an exception - obligate anaerobe bacterias). P450 oytochrome plays an important role in oxidation of numerous compounds of both endogenous origin (steroids, bilious acids, fatty acids, prostaglandins, leykotriyena, biogenous amines) and exogenous origin (drugs, poisons, products of industrial pollution, pesticides, carcinogens, mutagens, etc.). P450 eytochrome is an integral part of the biochemical protection system. They are classified as enzymes of phase I of xenobiotics biotransformation. The total activity of isoenzymes of CYP1 family (CYP1A1, CYP1A2 and CYP1B1) is approached as a summarized activity of EROD. The general knowledge on the systematic inclusion and function of EROD is summarized. A necessity to assess contribution of each isoenzyme into the summarized activity in EROD is substantiated.