Evolution in chemotherapy of human and animal helminthiases (review)

The attention is focused on the main classes of anthelmintics. Mode of action of the anthelmintics and the anthelmintic resistance, and alternative methods for dehelminthization are discussed. A targeted search for new anthelmintic substances in the series of speculative parental hydrocarbons (benzene, indene, naphthalene, 1 H1-cyclopenta [a]-naphthalene and phenanthrene) is suggested to be prospective on the basis of variation in their structure from the fully unsaturated to saturated forms, including those containing heteroatoms (N, O, S), various functional groups and substituents