On determination of reference chloroform content in children's blood

The author showed that consumption of chlorinated drinking water from centralized water supply systems with chloroform concentration being equal to 0.49 mg/l caused unacceptable non-carcinogenic risk (HI being up to 3.13) of functional disorders in the liver, kidneys, central nervous system, hormonal system, as well as the circulatory system. Assessment of carcinogenic health risk born by children revealed that individual carcinogenic risk was equal to 1.64 · 10-5 under such concentration; this value corresponds to the upper limit of acceptable risk. Morbidity analysis revealed that children who consumed chlorinated drinking water from water supply systems suffered from pathologies in the nervous system, digestive organs, urogenital and endocrine systems authentically more frequently. The results coincided with those obtained in non-carcinogenic health risk assessment. Epidemiologic assessment of children morbidity revealed an authentic cause-and-effect relationship between oral exposure to chloroform introduced with drinking water and diseases in critical organs and systems (according to Guide Р...