To the question of spatial differentiation of the Russian innovation system

Global changes in the production technologies of goods and services are connected with the development of the innovation system. Spatial differentiation plays an important role for the Russian Federation. It is associated with the in homogeneous distribution of eco-nomic activity and the historically formed structure of the economy, which ultimately de-termine the inhomogeneity of the economic space and in the spatial differentiation of the innovation system as well. A presented method for evaluating and analysing the structure of the innovation system by region confirms a significant inhomogeneity of the Russian Fed-eration subjects in terms of expenditures on technological innovations of organizations. The article presents the application areas of statistical tools for levelling the impact of econo-mies of scale of the regions with excess expenditures. We proposed measures aimed at overcoming adverse conditions and barriers for the transition of the national economy to the knowledge-model within the innovation system.