On the issue of mucocele therapy in small breed dogs

The aim of research is to study drugs based on ursodeoxycholic acid as part of complex therapy in small breed dogs with mucocele. The study was carried out on the basis of the Department of Anatomy and Physiology of the Federal State Budgetary Educational Institution of Higher Education of the Northern Trans-Urals State Agrarian University, as well as on the basis of veterinary clinics in the city of Tyumen. The object of the study is small breed dogs diagnosed with mucocele. To study the effectiveness of the applied treatment regimen, ultrasound diagnostics, blood serum analysis for AST, ALT, total bilirubin, and alkaline phosphatase were performed. When studying the ultrasonic features of the gallbladder during the period of admission of all animals, it was noted that its overflow is observed, the lumen is filled with echo-transparent contents with hypo- or hyperechoic clots without echo, which can almost completely overlap the entire lumen of the gallbladder. In this case, the wall is thin. The liver in some cases with signs of acute diffuse degenerative changes, but its size in all animals was within the normal range. Biochemical analysis of blood in the dogs under study showed an increase in all liver enzymes, total bilirubin, and alkaline phosphatase at the beginning of therapy. A treatment regimen was studied, in which, as part of standard therapy (antispasmodics, blockers of histamine H2 receptors of the third generation, an inhibitor of H+-K+-ATP-ase), drugs with the active ingredient ursodeoxycholic acid were added at a dose of 10 mg/kg (2 times a day in within 30 days). On the 30th day of therapy, there were no echo signs of the presence of sludge in 85 % of the dogs, and in all animals there was also a positive trend in the normalization of blood biochemical parameters. As a result of the study, it was revealed that the use of ursodeoxycholic acid as part of complex therapy has a positive effect on the dissolution of the mucocele of the gallbladder, and due to the possibility of a full discharge of bile, the biochemical composition of the blood is normalized.