Cardiotropic properties of chromone-3-aldehyde derivatives under an experimental cardiac infarction complicated with hypercholesterolemia

Cardiac infarction still remains a leading cause of mortality among population. There are a lot of risk factors causing the disease and complicating it; undoubtedly, they require correction. Our research goal was to experimentally assess cardiotropic peculiarities of 4 chromone-3-aldehyde derivatives (coded as Х3АF, Х3АFOK, X3ANO2, and X3ANO2ОК) as medications aimed at minimizing risks of acute cardiac infarction complicated with hypercholesterolemia. The experiment was performed on 70 male Wistar rats (pubescent, with body weight being equal to 220-240 grams); the animals were divided into 7 equal experimental groups, 10 animals in each. The first group was made up of falsely operated animals. We modeled atherogenesis in 60 remaining rats via oral introduction of 3 % cholesterol dissolved in sunflower oil; the solution was introduced daily for 14 days. We also modeled acute cardiac infarction in them via ligating the left descending coronary artery with a silk thread...