Valve-sparing aortic root replacement in patients with Marfan syndrome: a systematic review

Aim. To analyze the literature about the results of valve-sparing operations in aortic root surgery in patients with Marfan syndrome. Methods. A comprehensive search included four databases: Pubmed, Embase, Cochrane Library, and Web of Science. Articles for analysis were selected according to the methods presented in the PRISMA 2020 guidelines. Results. The final systematic review included 19 studies and 4 meta-analyses. The findings showed that 30-day and hospital mortality rates did not exceed 2.08%. The incidence of thromboembolism over a 15-year period was 4.1 ± 2.0%. The mean rate of infective endocarditis was 0.25%. Freedom from severe aortic insufficiency 8 years after surgery was 95.2 ± 3.3%. Freedom from reoperation at 8 and 10 years was 97%. Long-term mortality was