Клеточная линия MCF-7: характеристика и взаимодействие с наноматериалами разной структуры
Автор: Долгих М.Д., Заморина С.А.
Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio
Рубрика: Иммунология
Статья в выпуске: 2, 2024 года.
Бесплатный доступ
Приведена обобщённая информация о клеточной линии рака молочной железы MCF-7, которая представляет собой эпителиоподобную адгезивную клеточную линию, выделенную из аденокарциномы протоков молочной железы 69-летней женщины в одном из штатов США. Рассмотрена история получения клеточной линии и трудности, с которыми столкнулись учёные; её морфология; экспрессируемые внутриклеточные и поверхностные маркеры; генетические характеристики; применение в биомедицинских исследованиях: тестирование лекарственных препаратов, изучение биологии клеток и воздействующие на них факторы, разработка новых способов борьбы с раком молочной железы. В целом, клетки линии MCF-7 являются адекватной моделью для изучения множества параметров, таких как цитотоксичность; функциональная, пролиферативная и секреторная активности при взаимодействии с наночастицами разной структуры (в том числе металлическими, неметаллическими, органическими и их возможными комбинациями). В частности, более подробно проанализирована информация о взаимодействии углеродных наноматериалов с клетками MCF-7. Информация для статьи была взята из поисковых систем по научным публикациям: Google Академия, КиберЛенинка, PubMed; а также из официальных сайтов: NCBI, ATСC, сайт Российской коллекции клеточных культур позвоночных, Cytion. Глубина поиска с 1973 по март 2024 гг.
Mcf-7, адгезивная клеточная линия, аденокарцинома молочной железы, биомедицина, наночастицы, углеродные наноматериалы
Короткий адрес: https://sciup.org/147244926
IDR: 147244926 | DOI: 10.17072/1994-9952-2024-2-231-247
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