Клеточные и надклеточные уровни взаимодействия ретровирусов с хозяином на примере вируса бычьего лейкоза. Сообщение I. Проникновение в клетку и интеграция в геном хозяина

Клеточные и надклеточные уровни взаимодействия ретровирусов с хозяином на примере вируса бычьего лейкоза. Сообщение I. Проникновение в клетку и интеграция в геном хозяина

Автор: Глазко В.И., Косовский Г.Ю., Глазко Т.Т., Донник И.М.

Журнал: Сельскохозяйственная биология @agrobiology

Рубрика: Обзоры, проблемы

Статья в выпуске: 6 т.53, 2018 года.

Бесплатный доступ

Диагностика ретровирусных инфекций и предупреждение их распространения у животных сельскохозяйственных видов (в частности, низкая эффективность вакцинации) до сих пор все еще недостаточно разработаны прежде всего в связи с тем, что каскад событий, лежащий в основе взаимодействия ретровируса с объектом заражения имеет сложную иерархию и реализуется на разных уровнях организации - молекулярном (включая клеточные органеллы), собственно клеточном и надклеточном, связанным с функцией клеточных сетей иммунной системы. В настоящей работе представлен обзор собственных и имеющихся в литературе данных о взаимодействии ретровирусного патогена (на примере вируса бычьего лейкоза - bovine leukemia virus, BLV) с внутренними структурами клеток-мишеней. Анализ этих результатов позволил нам предположить, что ключевым фактором, определяющим интеграцию провирусной ДНК в геном хозяина при ретровирусной инфекции, может быть снижение внутриклеточного контроля транспозиций мобильных генетических элементов, тесно связанных по происхождению с ретровирусными инфекциями...

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Ретровирус, вирус бычьего лейкоза, инфекционный цикл, в-лимфоциты, рецептор вируса бычьего лейкоза, обратная транскриптаза, интеграза, мобильные генетические элементы

Короткий адрес: https://sciup.org/142220058

IDR: 142220058   |   DOI: 10.15389/agrobiology.2018.6.1093rus

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