Revascularization in combination with implantation of mononuclear fraction of autologous bone marrow when treating chronic coronary heart disease

The article focuses on clinical assessment of efficiency of transmyocardial laser revasularization (TMLR) in combination with implantation of mononuclear fraction of autologous bone marrow in 35 patients with diffuse, predominantly distal damage of the coronary bed. Ultrasonic cardiography data were used to analyze the patients' clinical state, dynamics of myocardial contractility and local contractility of the left ventricle, while perfusion scintigraphy data served for studying myocardium perfusion. The capacity of the myocardial capillary bed was determined by calculating the amount of oxygen consumed by the myocardium. Both short-term results (in 2 weeks after surgery) and long-term ones (in 6-8 months after surgery) were evaluated. Based on the results of the study, in the long-term period there was improvement of both total perfusion and perfusion in the area of indirect revascularization. Some improvement of global myocardial contractility and increase in the capacity of the myocardial capillary bed were found. While evaluating segmental contractility, a significant decrease in the quantity of akinetic segments was revealed, whereas the number of hypokinetic segments evidently remained the same.