Clinical and pharmacoeconomic results of the use of the protocol empiric antimicrobial therapy in a multidisciplinary hospital

Inappropriate starting antimicrobial therapy (AMT) is one of the main reasons for increasing the duration of hospitalization, treatment costs and mortality from severe infections. The main tool to improve the empirical AMT is a protocol based on local antimicrobial resistance data. The use of the protocol in the multidisciplinary hospital significantly reduces the consumption of antibiotics from 48,1 to 40,6 Defined Daily Dose (DDD) / 100 patient-days. The cost savings for the purchase of this group of drugs in 2014 compared to 2012 amounted 4 039 126 RUB. A significant reduction in the average duration of a course of AMT (15,7 days; 95% CI, 14-17,4 vs. 12,6 days; 95% CI, 11,3-13,9, p0,05) and the level of infection mortality (from 13,6%; 95% CI, 9,3-17,9 to 10%; 95% CI, 6,2-13,8, p>0,05) was detected.