Clinical trials of autologous vaccine on the base of tumor cells modified by tag-7 gene
Автор: Mikhailova I.N., Demidov L.V., Baryshnikov A.Yu., Burova O.S., Kharkevich G.Yu., Palkina T.N., Kozlov A.M., Morozova L.F., Vainson A.A., Kadagidze Z.G., Zabotina T.N., Burkova A.A., Doroshenko M.B., Khatyrev S.A., Nosov D.A., Tyulyandin S.A., Garin A.M., Kiselev S.L., Larin S.S., Georgiev G.P.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Клинические исследования
Статья в выпуске: 1 (13), 2005 года.
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Vaccinotherapy with gene-modified tumor cells was shown to be a promising treatment method for malignant tumors. The treatment method using autologous tumor cells transferred by tag-7 gene was developed. Pre-clinical investigations demonstrated specificity in vitro and in vivo and low toxicity of this method. Phase I clinical trials performed on 9 patients with disseminated melanoma and kidney cancer detected no side effects. The activated influence of this vaccine on immune system was found.
Короткий адрес: https://sciup.org/14054187
IDR: 14054187
