Clinical and immunological criteria for inflammation activity in infectious endocarditis

Certain prospects in identifying the bacterial nature of IE are associated with the determination of procalcitonin (PCT), the level of which naturally increases in sepsis. The results of the few studies in recent years devoted to the study of markers of inflammation (TNFa, CRP) and PCT reveal conflicting data on the value of these indicators in IE, often the absence of clinical and laboratory comparisons and their dynamic determination. IE leads to the development of circulatory failure (NK), often "resistant to therapy due to destruction of the valve apparatus.