Clinical-laboratory evaluation of lipid transport blood function in patients suffering from acute myocardial infarction with ST segment rise

Аim of the research - to evaluate the rates of lipid transport blood function in patients suffering from acute myocardial infarction with ST segment rise presenting in the ECG. Material and methods: 69 patients with acute myocardial infarction were examined. The lab research involved the lipid spectrum evaluation: total cholesterol (CH), triacylglycerol, cholesterol high-density lipoprotein, low-density lipoprotein, cholesterol very-low-density lipoprotein, apoprotein-A1, apoprotein-B, lipoprotein (a), oxidized modified low-density lipoprotein and antibodies to them. Results: The rise of general cholesterol and triacylglycerol rate (respectively for 20% and 80% in average), the rise of low-density lipoprotein, very-low-density lipoprotein, apoproteinB, lipoprotein (a) rate and decrease of cholesterol high-density lipoprotein, apoprotein-A rate were found in acute myocardial infarction patients as compared with respective rates in healthy persons. The gender differences were revealed: The women suffering from myocardial infarction have statistically relevant rise of general cholesterol, triacylglycerol, cholesterol low-density lipoprotein rate with decrease of cholesterol highdensity lipoprotein. The men have elevated level of apoprotein-B, the apoprotein-B/apoproteine-A ratio is also elevated and the apoprotein-A level is reduced. On the day 12th of observation the much higher level of triacylglycerol, apoprotein-B and elevated apoprotein-B/apoprotein-A ratio, as well as elevation of oxidized modified low-density lipoprotein and antibodies to them were observed in both examined groups. Summary: The definition of certain lipoprotein rate allows to evaluate the risk not only of ischemic heart disease development but of it's complications as well. Apoprotein-B and lipoprotein (a) are among target rates, which indicate the most exactly the atherogenic risk. These rates, used in addition to the rates of cholesterol low-density lipoprotein and cholesterol high-density lipoprotein, extend the potentialities of diagnosis and risk decrease of acute as well as recurrent coronary disorder development after medical treatment. Results range of application: cardiology.