Clinical and pathogenetic features, quality of life, diagnostics and prognosis in occupational chronic obstructive pulmonary diseas

Evaluation of functional characteristics and immunopathogenesis of occupational chronic obstructive pulmonary disease in its isolated and comorbid course opens up new possibilities in assessing the development, predicting the course features and personalized approach to pharmacotherapy of the studied bronchopulmonary pathology, as well as in developing an individual strategy for its primary and secondary prevention. The aim of the study is to determine the functional characteristics and immunological markers of the risk of developing occupational chronic obstructive pulmonary disease in its isolated course and in combination with arterial hypertension under conditions of exposure to industrial aerosols of chemical and fibrogenic nature. Object and methods. The study involved 175 patients and 60 control group individuals. Determination of the levels of cytokines IL-4, IL-6, IL-8, IL-10, MCP-1, FGF 2, TGF-b, vascular endothelial growth factor (VEGF) in the blood serum was carried out by the method of solid-phase enzyme immunoassay. All patients were tested using the SF-36 questionnaire ("SF-36 Health Status Survey"). For statistical processing of the data, one-way analysis of variance with intergroup comparisons according to Dunnett's criterion in the form of mean and standard deviation (M±SD), as well as comparison of the groups as a whole (ANOVA) were used. Results. For the first time, the features of functional and immunological manifestations of occupational chronic obstructive pulmonary disease were established in its isolated course depending on the severity and in its combined course with arterial hypertension. Conclusion. The revealed functional and immunological features of occupational chronic obstructive pulmonary disease in its isolated course depending on the severity and its combined comorbid course with arterial hypertension can optimize the approach to early diagnosis, prognosis, prevention and pharmacotherapy of the pathology under study.